Age-related changes in Tau and Autophagy in human brain in the absence of neurodegeneration

Abstract
Tau becomes abnormally hyper-phosphorylated and aggregated in tauopathies like Alzheimers disease (AD). As age is the greatest risk factor for developing AD, it is important to understand how tau protein itself, and the pathways implicated in its turnover, change during aging. We investigated age-related changes in total and phosphorylated tau in brain samples from two cohorts of cognitively normal individuals spanning 19-74 years, without overt...
Paper Details
Title
Age-related changes in Tau and Autophagy in human brain in the absence of neurodegeneration
Published Date
Aug 21, 2021
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