Co-receptor signaling in the pathogenesis of neuroHIV
Abstract
The HIV co-receptors, CCR5 and CXCR4, are necessary for HIV entry into target cells, interacting with the HIV envelope protein, gp120, to initiate several signaling cascades thought to be important to the entry process. Co-receptor signaling may also promote the development of neuroHIV by contributing to both persistent neuroinflammation and indirect neurotoxicity. But despite the critical importance of CXCR4 and CCR5 signaling to HIV...
Paper Details
Title
Co-receptor signaling in the pathogenesis of neuroHIV
Published Date
Aug 24, 2021
Journal
Volume
18
Issue
1
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