Profound Treg perturbations correlate with COVID-19 severity.

Abstract
The hallmark of severe COVID-19 is an uncontrolled inflammatory response, resulting from poorly understood immunological dysfunction. We hypothesized that perturbations in FoxP3+ T regulatory cells (Treg), key enforcers of immune homeostasis, contribute to COVID-19 pathology. Cytometric and transcriptomic profiling revealed a distinct Treg phenotype in severe COVID-19 patients, with an increase in Treg proportions and intracellular levels of the...
Paper Details
Title
Profound Treg perturbations correlate with COVID-19 severity.
Published Date
Sep 14, 2021
Volume
118
Issue
37
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