Loss of synergistic transcriptional feedback loops drives diverse B-cell cancers
Abstract
The most common B-cell cancers, chronic lymphocytic leukemia/lymphoma (CLL), follicular and diffuse large B-cell (FL, DLBCL) lymphomas, have distinct clinical courses, yet overlapping "cell-of-origin". Dynamic changes to the epigenome are essential regulators of B-cell differentiation. Therefore, we reasoned that these distinct cancers may be driven by shared mechanisms of disruption in transcriptional circuitry.We compared purified malignant...
Paper Details
Title
Loss of synergistic transcriptional feedback loops drives diverse B-cell cancers
Published Date
Sep 1, 2021
Journal
Volume
71
Pages
103559 - 103559
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