Osteopontin induces osteogenic differentiation by human periodontal ligament cells via calcium binding domain-activin receptor-like kinase (ALK-1) interaction

Background null Recently we have generated recombinant human osteopontin (rhOPN) using a plant platform (Nicotiana benthamiana) and demonstrated, when coated on culture plates, its osteogenic induction capacity of human periodontal ligament (PDL) cells. The aim of this study is to elucidate the molecular mechanism underlying the rhOPN-induced osteogenic differentiation of human PDL cells METHODS: Full length rhOPN (FL-OPN) and three constructs...