Mechanisms affecting brain remodeling in depression: do all roads lead to impaired fibrinolysis?
Abstract
Fibrinolysis occurs when plasminogen activators, such as tissue plasminogen activator (tPA), convert plasminogen to plasmin, which dissolves the fibrin clot. The proteolytic activity of tPA and plasmin is not restricted to fibrin degradation. In the extravascular space, these two proteases modify a variety of substrates other than fibrin, playing a crucial role in physiological and pathological tissue remodeling. In the brain, for example, tPA...
Paper Details
Title
Mechanisms affecting brain remodeling in depression: do all roads lead to impaired fibrinolysis?
Published Date
Aug 17, 2021
Journal
Volume
27
Issue
1
Pages
525 - 533
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