Genomic and Transcriptomic Characteristics of Esophageal Adenocarcinoma
Abstract
Esophageal adenocarcinoma (EAC) is a deadly disease with limited options for targeted therapy. With the help of next-generation sequencing studies over the last decade, we gained an understanding of the genomic architecture of EAC. The tumor suppressor gene TP53 is mutated in 70 to 80% of tumors followed by genomic alterations in CDKN2A, KRAS, ERBB2, ARID1A, SMAD4 and a long tail of less frequently mutated genes. EAC is characterized by a high...
Paper Details
Title
Genomic and Transcriptomic Characteristics of Esophageal Adenocarcinoma
Published Date
Aug 26, 2021
Journal
Volume
13
Issue
17
Pages
4300 - 4300
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