Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity

Background Aldehyde dehydrogenase (ALDH) is highly expressed in stem/progenitor cells in various tissues, and cell populations with high ALDH activity (ALDH br ) are associated with tissue repair. However, little is known about lung-resident ALDH br . This study was performed to clarify the characteristics of lung-resident ALDH br cells and to evaluate their possible use as a tool for cell therapy using a mouse model of bleomycin-induced...