CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy
Abstract
Targeting T cell malignancies with universal CD7-targeting chimeric antigen receptor T cells (UCART7) can lead to profound immune deficiency due to loss of normal T and NK cells. While a small population of endogenous CD7- T cells exists, these cells are unlikely to be able to repopulate the entire immune repertoire after UCART7 treatment, as they are limited in number and proliferative capacity. To rescue T and NK cells after UCART7, we created...
Paper Details
Title
CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy
Published Date
Aug 23, 2021
Journal
Volume
6
Issue
16
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