Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease
Abstract
Genetic, animal and epidemiological studies involving biomolecular and clinical endophenotypes implicate mitochondrial dysfunction in Alzheimer's disease (AD) pathogenesis. Polygenic risk scores (PRS) provide a novel approach to assess biological pathway-associated disease risk by combining the effects of variation at multiple, functionally related genes. We investigated the associations of PRS for genes involved in 12 mitochondrial pathways...
Paper Details
Title
Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease
Published Date
Dec 1, 2021
Journal
Volume
108
Pages
213 - 222
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