SO-26 In-silico Lynch syndrome-related neoantigens prediction for a dendritic cell-based cancer prevention vaccine

Lynch syndrome (LS), caused by germline mutations in DNA mismatch-repair genes (MLH1, MSH2, MSH6, PMS2) predisposes patients to colorectal and endometrial cancer (CRC, EC), among other tumors. Although CCR prevention methods are effective, no preventive strategies exist for the majority of LS-related tumors. Ex-vivo generated and tumor-antigen-loaded dendritic cell (DC) vaccines are one of the recently featured antitumoral immunotherapies....