Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers
Abstract
Next-generation T-cell therapies will likely continue to utilize T-cell receptors (TCRs) and chimeric antigen receptors (CARs) because each receptor type has advantages. TCRs often possess exceptional properties even when tested unmodified from patients' T cells. CARs are generally less sensitive, possibly because their ligand-binding domains are grafted from antibodies selected for binding affinity or avidity and not broadly optimized for a...
Paper Details
Title
Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers
Published Date
Aug 24, 2021
Journal
Volume
44
Issue
8
Pages
292 - 306
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