NHC-catalyzed enantioselective C2-functionalization of 3-hydroxychromenones via α,β-unsaturated acyl azoliums
Abstract
A novel synthetic method for enantioselective C2-functionalization of 3-hydroxychromenones promoted by N-heterocyclic carbenes via the formation of α,β-unsaturated acyl azolium intermediates, which occurs with Coates–Claisen rearrangement is established. This synthetic strategy enabled the rapid assembly of enantiomerically enriched δ-hydroxychromenone-derived esters/amides under mild conditions with good to excellent yields and broad substrate...
Paper Details
Title
NHC-catalyzed enantioselective C2-functionalization of 3-hydroxychromenones via α,β-unsaturated acyl azoliums
Published Date
Sep 30, 2021
Journal
Volume
57
Issue
78
Pages
9999 - 10002
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