Non-inferiority in cancer clinical trials was associated with more lenient margins and higher hypothesized outcome event rates

To identify potential bias in non-inferiority design of published cancer trials, and to provide suggestions for future practice.We systematically searched MEDLINE, Embase and CENTRAL databases (until April 17, 2020) to obtain non-inferiority phase III cancer trials and protocols. Distribution of essential characteristics and study design parameters was compared between trials with and without concluding non-inferiority using multivariable...