Current advances in overcoming obstacles of CRISPR/Cas9 off-target genome editing
Abstract
CRISPR/Cas9-based technology has revolutionized biomedical research by providing a high-fidelity gene-editing method, foreshadowing a significant impact on the therapeutics of many human genetic disorders previously considered untreatable. However, off-target events represent a critical hurdle before genome editing can be fully established in clinical practice. This mini-review recapitulates some recent advances for detecting and overcoming...
Paper Details
Title
Current advances in overcoming obstacles of CRISPR/Cas9 off-target genome editing
Published Date
Sep 1, 2021
Volume
134
Issue
1-2
Pages
77 - 86
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