RNA editing restricts hyperactive ciliary kinases

Science56.90
Volume: 373, Issue: 6558, Pages: 984 - 991
Published: Aug 27, 2021
Abstract
RNA editing restricts ciliary kinases Ciliary kinases are essential for cilia formation and function, but it remains unknown how their activities are regulated in vivo. Li et al . created roundworm animal models carrying hyperactive ciliary kinases that disrupt cilia. Their genetic suppressor screens revealed that loss of an RNA adenosine deaminase, which catalyzes adenosine-to-inosine (A-to-I) RNA editing, rescued ciliary abnormalities. They...
Paper Details
Title
RNA editing restricts hyperactive ciliary kinases
Published Date
Aug 27, 2021
Journal
Volume
373
Issue
6558
Pages
984 - 991
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