Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity
Abstract
Oxidative stress plays a key role in the development of metabolic complications associated with obesity, including insulin resistance and the most common chronic liver disease worldwide, nonalcoholic fatty liver disease. We have recently discovered that the microRNA miR-144 regulates protein levels of the master mediator of the antioxidant response, nuclear factor erythroid 2-related factor 2 (NRF2). On miR-144 silencing, the expression of NRF2...
Paper Details
Title
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity
Published Date
Dec 1, 2021
Journal
Volume
161
Issue
6
Pages
1982 - 1997.e11
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