The Mediator captures CDK7, an attractive transcriptional target in cancer
Abstract
Cyclin-dependent kinase 7 (CDK7) is implicated in regulating the expression of cancer-dependent genes, and multiple CDK7-targeted therapies are currently under clinical investigation. Three recent studies elucidate the structure of human transcription machinery, offering vital mechanistic insights into CDK7 function and a potential pharmacodynamic marker of CDK7 activity in...
Paper Details
Title
The Mediator captures CDK7, an attractive transcriptional target in cancer
Published Date
Sep 1, 2021
Journal
Volume
39
Issue
9
Pages
1184 - 1186
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