Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice
Abstract
Fetal growth restriction (FGR) is a complication of pregnancy that reduces birth weight, markedly increases infant mortality and morbidity and is associated with later-life cardiometabolic disease. No specific treatment is available for FGR. Placentas of human FGR infants have low abundance of sodium-coupled neutral amino acid transporter 2 (Slc38a2/SNAT2), which supplies the fetus with amino acids required for growth. We determined the...
Paper Details
Title
Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice
Published Date
Aug 31, 2021
Journal
Volume
135
Issue
17
Pages
2049 - 2066
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