Pre-clinical development and molecular characterization of an engineered type 1 regulatory T-cell product suitable for immunotherapy
Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapeutic approach for many hematological disorders. However, allo-HSCT is frequently accompanied by a serious side effect: graft-versus-host disease (GVHD). The clinical use of allo-HSCT is limited by the inability of current immunosuppressive regimens to adequately control GvHD without impairing the graft-versus-leukemia effect (GvL) conferred by transplanted...
Paper Details
Title
Pre-clinical development and molecular characterization of an engineered type 1 regulatory T-cell product suitable for immunotherapy
Published Date
Nov 1, 2021
Journal
Volume
23
Issue
11
Pages
1017 - 1028
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