Executive Functioning in Chinese Patients With Obsessive Compulsive Disorder

Published on Jan 1, 2021in Frontiers in Psychiatry2.849
· DOI :10.3389/FPSYT.2021.662449
Huicong Ren , Haibin Li + 5 AuthorsChencheng Zhang6
Estimated H-index: 6
(SJTU: Shanghai Jiao Tong University)
#1Iveta FajnerováH-Index: 8
#2David Gregus (Charles University in Prague)H-Index: 2
Last. Jiri Horacek (Charles University in Prague)H-Index: 26
view all 8 authors...
Introduction: Deficits in neurocognitive mechanisms such as inhibition control and cognitive flexibility have been suggested to mediate the symptoms in obsessive-compulsive disorder (OCD). These mechanisms are proposedly controlled by the "affective" and "executive" orbitofronto-striato-thalamo-cortical (CSTC) circuits with well-documented morphological and functional alterations in OCD that are associated with OCD symptoms. The precuneus region has been suggested in OCD as another key structure...
2 CitationsSource
#2Farshid ShamsaeiH-Index: 9
Last. Ali GhaleihaH-Index: 19
view all 7 authors...
Abstract Obsessive–compulsive disorder (OCD) is associated with cognitive dysfunction. Deeper and wider knowledge of the cognitive components of these patients can play an important role in better understanding of this disorder. This study aimed to compare executive function, selective attention and information processing in OCD patients and healthy controls. The current study was performed on 54 patients meeting DSM-5 criteria for OCD and 54 healthy subjects who matched with patients in gender,...
11 CitationsSource
#1Nikolina Skandali (University of Cambridge)H-Index: 11
#2James B. Rowe (University of Cambridge)H-Index: 78
Last. Barbara J. Sahakian (University of Cambridge)H-Index: 156
view all 12 authors...
Serotonin is implicated in multiple executive functions including goal-directed learning, cognitive flexibility, response inhibition and emotional regulation. These functions are impaired in several psychiatric disorders, such as depression and obsessive–compulsive disorder. We tested the cognitive effects of the selective serotonin reuptake inhibitor escitalopram, using an acute and clinically relevant dose (20 mg), in 66 healthy male and female volunteers in a double-blind, placebo-controlled ...
35 CitationsSource
Planning ability (PA) is a key aspect of cognitive functioning and requires subjects to identify and organise the necessary steps to achieve a goal. Despite the central role of executive dysfunction in patients with obsessive–compulsive disorder (OCD), deficits in PA have been investigated leading to contrasting results. Given these inconsistencies, the main aim of our work is to give a deeper and clearer understanding of PA in OCD patients. Moreover, we are interested in investigating the relat...
5 CitationsSource
#1Matthew E. Hirschtritt (UCSF: University of California, San Francisco)H-Index: 17
#2Michael H. Bloch (Yale University)H-Index: 61
Last. Carol A. Mathews (UF: University of Florida)H-Index: 56
view all 3 authors...
Importance Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder associated with significant impairment and a lifetime prevalence of 1% to 3%; however, it is often missed in primary care settings and frequently undertreated. Objective To review the most current data regarding screening, diagnosis, and treatment options for OCD. Evidence Review We searched PubMed, EMBASE, and PsycINFO to identify randomized controlled trials (RCTs), meta-analyses, and systematic reviews that addresse...
170 CitationsSource
#1Hannah R. Snyder (DU: University of Denver)H-Index: 22
#2Roselinde H. Kaiser (Harvard University)H-Index: 16
Last. Wendy Heller (UIUC: University of Illinois at Urbana–Champaign)H-Index: 55
view all 4 authors...
Obsessive-compulsive disorder (OCD) is a serious and often chronically disabling condition. The current dominant model of OCD focuses on abnormalities in prefrontal-striatal circuits that support executive function (EF). Although there is growing evidence for EF impairments associated with OCD, results have been inconsistent, which makes the nature and magnitude of these impairments controversial. The current meta-analysis uses random-effects models to synthesize 110 studies in which participant...
168 CitationsSource
#1Wayne K. Goodman (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 102
#2Dorothy E. Grice (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 30
Last. Barbara J. Coffey (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 42
view all 4 authors...
Obsessive-compulsive disorder (OCD) is a psychiatric illness that can be quite debilitating and historically has proven difficult to treat. Research conducted over the past decade has provided much insight into the underlying neuropathology, allowing significant advances in the treatment of these patients. Whereas psychotherapy was previously the only mode of treatment for OCD, pharmacological agents and psychosurgical procedures are proving to be effective in treating this disorder. The use of ...
86 CitationsSource
#1David Veale (South London and Maudsley NHS Foundation Trust)H-Index: 46
#2Alison Roberts (South London and Maudsley NHS Foundation Trust)H-Index: 1
#### Summary points Obsessive-compulsive disorder (OCD) is characterised by the presence of obsessions or compulsions, or commonly of both. OCD is the fourth most common mental disorder after depression, alcohol/substance misuse, and social phobia, with a lifetime prevalence in community surveys of 1.6%.1 The severity of OCD differs markedly from one person to another. People are often able to hide their OCD, even from their own family, although it can cause problems in relationships and interfe...
71 CitationsSource
#1Na Young Shin (SNU: Seoul National University)H-Index: 16
#2Tae Young Lee (SNU: Seoul National University)H-Index: 19
Last. Jun Soo Kwon (SNU: Seoul National University)H-Index: 77
view all 4 authors...
Background Substantial empirical evidence has indicated impairment in the cognitive functioning of patients with obsessive-compulsive disorder (OCD) despite inconsistencies. Although several confounding factors have been investigated to explain the conflicting results, the findings remain mixed. This study aimed to investigate cognitive dysfunction in patients with OCD using a meta-analytic approach. Method The PubMed database was searched between 1980 and October 2012, and reference lists of re...
180 CitationsSource
#1Amitai Abramovitch (Harvard University)H-Index: 19
#2Jonathan S. Abramowitz (UNC: University of North Carolina at Chapel Hill)H-Index: 92
Last. Andrew Mittelman (Harvard University)H-Index: 9
view all 3 authors...
article i nfo A vast and heterogeneous body of literature on the neuropsychology of obsessive-compulsive disorder (OCD) has accumulated in recent decades, yielding inconsistent results. In an attempt to quantitatively summarize the literature, we conducted a meta-analysis of 115 studies (including 3452 patients), comparing adult OCD pa- tients with healthycontrols on testsof10neuropsychologicaldomains.Acrossstudies, medium meaneffectsizes were found for all executive function subdomains, process...
253 CitationsSource
Cited By0