A novel and oral colon targeted isoliquiritigenin delivery system: Development, optimization, characterization and in vitro evaluation

The aims of the study were to prepare oral colon targeted gel beads loaded with isoliquiritigenin (ISL) which exhibited a variety of biological activities with a low solubility and oral bioavailability. ISL loaded sodium alginate and pectin gel beads (SA-P gel beads) were prepared by ionic gel technique, and Uniform Design method was used to optimize the formulation. To decrease the leakage in simulated gastric juice and simulated intestinal...