Immune Cell β2-Adrenergic Receptors Contributes to the Development of Heart Failure

Published on Aug 20, 2021in American Journal of Physiology-heart and Circulatory Physiology3.864
· DOI :10.1152/AJPHEART.00243.2021
Miles A. Tanner16
Estimated H-index: 16
(MU: University of Missouri),
Charles A. Maitz4
Estimated H-index: 4
(MU: University of Missouri),
Laurel A. Grisanti5
Estimated H-index: 5
(MU: University of Missouri)
Sources
Abstract
β-Adrenergic receptors (βAR) regulate normal and pathophysiological heart function through their impact on contractility. βAR are also regulators of immune function where they play a unique role de...
📖 Papers frequently viewed together
10 Citations
11 Citations
2003
1 Author (Toru Kubota)
References76
Newest
#1Miles A. Tanner (MU: University of Missouri)H-Index: 16
#2Toby P. Thomas (MU: University of Missouri)H-Index: 2
Last. Laurel A. Grisanti (MU: University of Missouri)H-Index: 5
view all 4 authors...
Fibroblasts are an important resident cell population in the heart involved in maintaining homeostasis and structure during normal conditions. They are also crucial in disease states for sensing signals and initiating the appropriate repair responses to maintain the structural integrity of the heart. This sentinel role of cardiac fibroblasts occurs, in part, through their ability to secrete cytokines. β-adrenergic receptors (βAR) are also critical regulators of cardiac function in the normal and...
7 CitationsSource
#1Elisa MartiniH-Index: 7
#2Paolo KunderfrancoH-Index: 18
Last. Marinos Kallikourdis (Humanitas University)H-Index: 17
view all 24 authors...
Background: Inflammation is a key component of cardiac disease, with macrophages and T lymphocytes mediating essential roles in the progression to heart failure (HF). Nonetheless, little insight ex...
64 CitationsSource
#1Miles A. Tanner (MU: University of Missouri)H-Index: 16
#2Toby P. Thomas (MU: University of Missouri)H-Index: 2
Last. Laurel A. Grisanti (MU: University of Missouri)H-Index: 5
view all 3 authors...
Abstract Cardiomyocyte survival and death contributes to many cardiac diseases. A common mechanism of cardiomyocyte death is through apoptosis however, numerous death receptors (DR) have been virtually unstudied in the context of cardiovascular disease. Previous studies have identified TNF-related apoptosis inducing ligand (TRAIL) and its receptor, DR5, as being altered in a chronic catecholamine administration model of heart failure, and suggest a role of non-canonical signaling in cardiomyocyt...
6 CitationsSource
#1Francisco J. Carrillo-Salinas (Tufts University)H-Index: 20
#2Njabulo Ngwenyama (Tufts University)H-Index: 4
Last. Pilar Alcaide (Tufts University)H-Index: 29
view all 5 authors...
Heart failure (HF) has been traditionally viewed as a disease of the cardiac muscle associated with systemic inflammation. Burgeoning evidence implicates immune effector mechanisms that include immune cell activation and trafficking to the heart. Immune cell infiltration in the myocardium can have adverse effects in the heart and contribute to the pathogenesis of HF. Both innate and adaptive immunity operate sequentially, and the specificity of these responses depends on the initial trigger sens...
15 CitationsSource
#1Laurel A. Grisanti (MU: University of Missouri)H-Index: 5
#2Claudio de LuciaH-Index: 20
Last. Douglas G. TilleyH-Index: 29
view all 15 authors...
Following injury, leukocytes are released from hematopoietic organs and migrate to the site of damage to regulate tissue inflammation and repair; however, leukocytes lacking β2-adrenergic receptor (β2-AR) expression have marked impairments in these processes. Beta blockade is a common strategy for the treatment of many cardiovascular etiologies; therefore, the objective of our study was to assess the impact of prior beta blocker treatment on baseline leukocyte parameters and their responsiveness...
11 CitationsSource
#1Sarah-Lena Puhl (LMU: Ludwig Maximilian University of Munich)H-Index: 2
#2Sabine Steffens (LMU: Ludwig Maximilian University of Munich)H-Index: 52
Inflammation not only plays a crucial role in acute ischemic cardiac injury, but also contributes to post-infarction repair and remodeling. Traditionally, neutrophils have been merely considered as detrimental in the setting of an acute myocardial infarction. However, recently published studies demonstrated that neutrophils might also play an important role in cardiac repair by regulating reparative processes. An emerging concept is that different neutrophil subsets exist, which might exhibit se...
45 CitationsSource
#1Li Wu (Anhui Medical University)H-Index: 8
#2Yu Tai (Anhui Medical University)H-Index: 6
Last. Wei Wei (Anhui Medical University)H-Index: 73
view all 10 authors...
Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of β2-AR, as well as different subtypes of Gα binding to β2-AR. In this review, we summarize the act...
15 CitationsSource
#1Shuin Park (UCLA: University of California, Los Angeles)H-Index: 4
#2Sara Ranjbarvaziri (UCLA: University of California, Los Angeles)H-Index: 5
Last. Reza ArdehaliH-Index: 28
view all 15 authors...
Background: Genetic diversity and the heterogeneous nature of cardiac fibroblasts (CFbs) have hindered characterization of the molecular mechanisms that regulate cardiac fibrosis. The Hybrid Mouse ...
26 CitationsSource
#1Laurel A. Grisanti (MU: University of Missouri)H-Index: 5
#2Toby P. Thomas (TU: Temple University)H-Index: 3
Last. Douglas G. Tilley (TU: Temple University)H-Index: 29
view all 8 authors...
Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro; thus, we hypothesize that this pathway can mitigate cardiomyocyte death at the time of reperfusion to better preserve function. However, a lack of efficacious βarr-biased orthosteric small molecules has prevented investigation into whether this pa...
19 CitationsSource
#1Claudio de Lucia (TU: Temple University)H-Index: 20
#2Akito Eguchi (TU: Temple University)H-Index: 5
Last. Walter J. Koch (TU: Temple University)H-Index: 99
view all 3 authors...
Heart failure has become increasingly common within the elderly population, decreasing their survival and overall quality of life. In fact, despite the improvements in treatment, many elderly people suffer from cardiac dysfunction (heart failure, valvular diseases, arrhythmias or hypertension-induced cardiac hypertrophy) that are much more common in an older fragile heart. Since β-adrenergic receptor (β-AR) signaling is abnormal in failing as well as aged hearts, this pathway is an effective dia...
108 CitationsSource
Cited By0
Newest