Gene Expression and Protein Abundance of Hepatic Drug Metabolizing Enzymes in Liver Pathology
Abstract
Hepatic drug metabolizing enzymes (DMEs) markedly affect drug pharmacokinetics. Because liver diseases may alter enzymatic function and in turn drug handling and clinical efficacy, we investigated DMEs expression in dependence on liver pathology and liver failure state. In 5 liver pathologies (hepatitis C, alcoholic liver disease, autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis) and for the first time...
Paper Details
Title
Gene Expression and Protein Abundance of Hepatic Drug Metabolizing Enzymes in Liver Pathology
Published Date
Aug 25, 2021
Journal
Volume
13
Issue
9
Pages
1334 - 1334
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