Effervescent floating matrix tablets of a novel anti-cancer drug neratinib for breast cancer treatment

The main purpose of this study was to develop a novel gastro-retentive drug delivery system via effervescent technique for the treatment of breast cancer. Neratinib (NTB) is a novel anticancer drug, poorly soluble at higher pH, was been used as a model drug and an attempt was made to develop a floating tablet using hydroxypropyl methylcellulose-90SH 15000 (HPMC-90SH 15000), microcrystalline cellulose, sodium bicarbonate, talc and lactose using...