Large Between-Patient Variability in eGFR Decline before Clinical Trial Enrollment and Impact on Atrasentan’s Efficacy: A Post Hoc Analysis from the SONAR Trial

Patients with high albuminuria and low eGFR levels are usually enrolled in clinical trials to enrich the population at risk of ESKD in order to accrue sufficient clinical end points. However, the relatively low event rates in recent nephrology trials suggest that this approach does not completely rule out enrollment of patients without progressive kidney function loss.12–3 The rate of eGFR decline before trial entry (pretrial eGFR slope) is a...