The anti-proliferative and anti-metastatic effects of ONC206 are potentiated by olaparib in serous ovarian cancer
Abstract
Objectives: The imipridone ONC206, a chemical derivative of ONC201, is a bioavailable dopamine receptor D2 (DRD2) antagonist that has anti-tumorigenic effects via induction of apoptosis and activation of the integrated stress response. ONC206 exhibits differentiated receptor pharmacology, nanomolar potency, and enhanced bioavailability relative to ONC201. Olaparib is a poly ADP-ribose polymerase inhibitor (PARPi) approved for use as maintenance...
Paper Details
Title
The anti-proliferative and anti-metastatic effects of ONC206 are potentiated by olaparib in serous ovarian cancer
Published Date
Aug 1, 2021
Journal
Volume
162
Pages
S288 - S288
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Notes
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