Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice
Abstract
Sirtuin-1 (SIRT1) is involved in various metabolic pathways, including fatty acid synthesis and gluconeogenesis in the liver. However, its role in initiation and progression of liver cancer remains unclear. Studying Sirt1 liver-specific knockout (LKO) mice in combination with diethylnitrosamine (DEN) treatment, we demonstrated that loss of Sirt1 rendered mice resistant to DEN-induced hepatocellular carcinoma (HCC) development. RNA-seq revealed...
Paper Details
Title
Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice
Published Date
Aug 25, 2021
Journal
Volume
40
Issue
41
Pages
6023 - 6033
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