Function (biology)

Cell biology

Reproductive technology

Biology

Human fertilization

Sperm

Fertilisation

Endocrinology

Acrosome reaction

Biochemistry

Environmental health

Genetics

Homeostasis

Embryo

Acrosome

Embryogenesis

Fertility

Population

Lipid metabolism

Andrology

Medicine

Capacitation

International Journal of Molecular Sciences

Sperm plasma membrane lipids are essential for the function and integrity of mammalian spermatozoa. Various lipid types are involved in each key step within the fertilization process in their own yet coordinated way. The balance between lipid metabolism is tightly regulated to ensure physiological cellular processes, especially referring to crucial steps such as sperm motility, capacitation, acrosome reaction or fusion. At the same time, it has been shown that male reproductive function depends on the homeostasis of sperm lipids. Here, we review the effects of phospholipid, neutral lipid and glycolipid homeostasis on sperm fertilization function and male fertility in mammals.

Sperm Lipid Markers of Male Fertility in Mammals