Transcriptomic Changes Following Partial Depletion of CENP-E in Normal Human Fibroblasts
Abstract
The centromere is a fundamental chromosome structure in which the macro-molecular kinetochore assembles and is bound by spindle microtubules, allowing the segregation of sister chromatids during mitosis. Any alterations in kinetochore assembly or functioning or kinetochore-microtubule attachments jeopardize chromosome stability, leading to aneuploidy, a common feature of cancer cells. The spindle assembly checkpoint (SAC) supervises this...
Paper Details
Title
Transcriptomic Changes Following Partial Depletion of CENP-E in Normal Human Fibroblasts
Published Date
Aug 26, 2021
Journal
Volume
12
Issue
9
Pages
1322 - 1322
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