Myeloid differentiation protein‐2 has a protective role in house dust mite‐mediated asthmatic characteristics with the proinflammatory regulation of airway epithelial cells and dendritic cells

Myeloid differentiation protein-2 (MD-2) is a lipopolysaccharide-binding protein involved in lipopolysaccharide signalling via Toll-like receptor 4 (TLR4). TLR4 plays an essential role in HDM-mediated allergic airway inflammation. Moreover, MD-2 is structurally similar to Der f 2, a major allergen from house dust mite (HDM).We aimed to clarify the role of MD-2 in the pathogenesis of HDM-mediated allergic airway inflammation.Wild-type (WT), TLR4...