Duchenne muscular dystrophy patients: troponin leak in asymptomatic and implications for drug toxicity studies
Abstract
Cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD), but studies suggest heart failure biomarkers correlate poorly with cardiomyopathy severity. DMD clinical trials have used troponin I (cTnI) as a biomarker of toxicity, but it is unclear if asymptomatic DMD patients have elevated cTnI. We longitudinally evaluated cTnI, brain natriuretic peptide (BNP), and N-terminal pro-BNP (NT-proBNP) in a DMD cohort.DMD patients...
Paper Details
Title
Duchenne muscular dystrophy patients: troponin leak in asymptomatic and implications for drug toxicity studies
Published Date
Aug 24, 2021
Journal
Volume
92
Issue
6
Pages
1613 - 1620
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