Involvement of galanin and galanin receptor 2 in a mouse model of allergic rhinitis

Allergic rhinitis (AR) is caused by allergic reaction to allergens such as pollen. Galanin (GAL), a neuropeptide that regulates inflammatory processes, is widely expressed in the central and peripheral nervous systems. Although neuropeptides are implicated in arthritis and chemically induced ileitis, their roles in AR remain unclear.We developed a murine model of AR and generated control, systemic sensitization, mild AR, and severe AR groups. We...