Comparison of analytical methods for antibody conjugates with application in nuclear imaging – Report from the trenches
Abstract
Monoclonal antibodies (mAbs) are widely used in nuclear imaging. Radiolabelling with positron emitting radionuclides, typically radiometals, requires the incorporation of a bifunctional chelator for the formation of the radiometal-mAb complex. Additionally, mAbs can be conjugated with small molecules capable to undergo bioorthogonal click reactions in vivo, enabling pre-targeting strategies. The determination of the number of functionalities...
Paper Details
Title
Comparison of analytical methods for antibody conjugates with application in nuclear imaging – Report from the trenches
Published Date
Nov 1, 2021
Journal
Volume
102-103
Pages
24 - 33
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