Facile Synthesis of Chiral Arylamines, Alkylamines and Amides by Enantioselective NiH-Catalyzed Hydroamination

Published on Aug 27, 2021in Angewandte Chemie12.959
· DOI :10.1002/ANIE.202109881
Lingpu Meng (NU: Nanjing University), Jingjie Yang (NU: Nanjing University)+ 2 AuthorsShaolin Zhu20
Estimated H-index: 20
(NU: Nanjing University)
Sources
Abstract
Regio- and enantioselective hydroarylamination, hydroalkylamination and hydroamidation of styrenes have been developed by NiH catalysis with a simple bioxazoline ligand under mild conditions. A wide range of enantioenriched benzylic arylamines, alkylamines and amides can be easily accessed by nitroarenes, hydroxylamines and dioxazolones, respectively as amination reagents. The chiral induction in these reactions is proposed to proceed through an enantiodifferentiating syn-hydronickellation step.
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