Overexpression of BMP4 protects retinal ganglion cells in a mouse model of experimental glaucoma

Activation of bone morphogenetic protein (BMP) 4 signaling promotes the survival of retinal ganglion cell (RGC) after acute injury. Chordin-like 1 (CHRDL1) is an endogenous BMP antagonist. In this study, we researched whether CHRDL1 was involved in BMP4 signaling and regulation of RGC degeneration in a mouse model of glaucoma. Magnetic microbeads were intracameral injected to induce experimental glaucoma in a mouse model. A recombinant...