Inhibition of the Arp2/3 complex represses human lung myofibroblast differentiation and attenuates bleomycin‐induced pulmonary fibrosis

Background and Purpose The Arp2/3 multiprotein complex regulates branched polymerisation of the actin cytoskeleton and may contribute to collagen synthesis and fibrogenesis in the lung. Experimental Approach Expression of Arp2/3 components was assessed in human lung fibroblasts and in the bleomycin‐induced pulmonary fibrosis model in mice. The Arp2/3 complex was repressed with the allosteric inhibitor CK666 and with interfering RNAs targeting...