Aluminium in cosmetics and personal care products.

Published on Aug 15, 2021in Journal of Applied Toxicology2.997
· DOI :10.1002/JAT.4228
Sonia Sanajou1
Estimated H-index: 1
(EMU: Eastern Mediterranean University),
Gonul Sahin21
Estimated H-index: 21
(EMU: Eastern Mediterranean University),
Terken Baydar15
Estimated H-index: 15
(Hacettepe University)
Usage of inorganic ingredients like aluminium salts in cosmetics and personal care products has been a concern for producers and consumers. Although aluminium is used to treat hyperhidrosis, some worries have been raised about aluminium's role in breast cancer, breast cyst and Alzheimer's disease. The human population is exposed to aluminium from vaccines, diet, and drinking water, but the frequent use of aluminium-based cosmetics might add additional local exposure. This paper reviews literature to determine if aluminium-based products may pose potential harm to the body. The dermal absorption of aluminium is not widely understood. It is not yet known whether aluminium can travel from the skin to brain to cause Alzheimer's disease. Aluminium may cause gene instability, alter gene expression or enhance oxidative stress, but the carcinogenicity of aluminium has not been proved yet. Until now, epidemiological researches were based on oral information, which lacks consistency, and the results are conflicting. Future studies should target real-life-based long-time exposure to antiperspirants and other aluminium-containing cosmetics and personal care products.
#1Xueqing Hu (BTBU: Beijing Technology and Business University)
#2Huaming He (BTBU: Beijing Technology and Business University)
BACKGROUND Cosmetic Skin Delivery has a very important impact on the action of cosmetics. More and more cosmetic manufacturers are focusing on cosmetic delivery. Meanwhile, it also brings safety issues and the customization of national laws and regulations. OBJECTIVES This paper reviews the theoretical knowledge about cosmetic skin delivery and evaluation methods. METHODS An extensive literature search was conducted using PubMed, Web of Science, and other databases for articles on transdermal/sk...
1 CitationsSource
#1Matthew Mold (Keele University)H-Index: 12
#2Adam O'Farrell (Keele University)H-Index: 1
Last. Christopher Exley (Keele University)H-Index: 59
view all 4 authors...
2 CitationsSource
#1Maximilian Letzel (FAU: University of Erlangen-Nuremberg)H-Index: 1
#2Hans Drexler (FAU: University of Erlangen-Nuremberg)H-Index: 48
Last. Julia Hiller (FAU: University of Erlangen-Nuremberg)H-Index: 4
view all 4 authors...
BACKGROUND AND OBJECTIVES: Adverse health effects such as neurotoxic and carcinogenic effects through aluminum from cosmetic products have been repeatedly discussed. The dermal uptake and impact on the systemic aluminum load is still poorly understood. Therefore, we investigated the effect of daily antiperspirant use on the systemic aluminum load under real-life conditions. METHODS: 21 healthy subjects meeting certain selection criteria to ensure a low systemic aluminum background load were aske...
4 CitationsSource
#1Ulrike BernauerH-Index: 14
#2Laurent BodinH-Index: 4
Last. Wolfgang UterH-Index: 78
view all 18 authors...
2 Citations
#1Thomas Tietz (BfR: Federal Institute for Risk Assessment)H-Index: 3
#2Ariane Lenzner (BfR: Federal Institute for Risk Assessment)H-Index: 1
Last. Andreas Hensel (BfR: Federal Institute for Risk Assessment)H-Index: 16
view all 21 authors...
Aluminium is one of the most abundant elements in earth’s crust and its manifold uses result in an exposure of the population from many sources. Developmental toxicity, effects on the urinary tract and neurotoxicity are known effects of aluminium and its compounds. Here, we assessed the health risks resulting from total consumer exposure towards aluminium and various aluminium compounds, including contributions from foodstuffs, food additives, food contact materials (FCM), and cosmetic products....
25 CitationsSource
#1Ikechukwu Onyebuchi Igbokwe (University of Maiduguri)H-Index: 15
#2Ephraim Igwenagu (University of Maiduguri)H-Index: 4
Last. Nanacha Afifi Igbokwe (University of Maiduguri)H-Index: 5
view all 3 authors...
Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or transformation, enzymatic dysfunction, metabolic derangement, amyloidogenesis, membrane perturbation, ...
41 CitationsSource
#1Shiri Nawrocki (RU: Rutgers University)H-Index: 4
#2Jisun Cha (RU: Rutgers University)H-Index: 3
Hyperhidrosis (HH) is a chronic disorder of excess sweat production that may have a significant adverse effect on quality of life. A variety of treatment modalities currently exist to manage HH. Initial treatment includes lifestyle and behavioral recommendations. Antiperspirants are regarded as the first-line therapy for primary focal HH and can provide significant benefit. Iontophoresis is the primary remedy for palmar and plantar HH. Botulinum toxin injections are administered at the dermal-su...
37 CitationsSource
A large number of possible risk factors have been associated with Alzheimer'sdisease (AD).This chapter discusses the validity of the major risk factors that have been identifiedincluding age, genetics, exposure to aluminum, head injury, malnutrition and diet,mitochondrial dysfunction, vascular disease, immune system dysfunction, and infectionand proposes a hypothesis to explain how these various risk factors may cause ADpathology.Rare forms of early-onset familial AD (FAD) are strongly linked to...
76 CitationsSource
A clinical pharmacokinetic study was performed in 12 healthy women to evaluate systemic exposure to aluminum following topical application of a representative antiperspirant formulation under real-life use conditions. A simple roll-on formulation containing an extremely rare isotope of aluminum (26 Al) chlorohydrate (ACH) was prepared to commercial specifications. A 26 Al radio-microtracer was used to distinguish dosed aluminum from natural background, using accelerated mass spectroscopy. The 26...
11 CitationsSource
#1Ulrike BernauerH-Index: 14
#2Laurent BodinH-Index: 11
Last. N. Von GoetzH-Index: 2
view all 19 authors...
The SCCS adopted this guidance document at its plenary meeting on 24 – 25 October 2018 (152 pages)
53 Citations
Cited By0