Aluminium in cosmetics and personal care products.

Published on Aug 15, 2021in Journal of Applied Toxicology2.997
· DOI :10.1002/JAT.4228
Sonia Sanajou1
Estimated H-index: 1
(EMU: Eastern Mediterranean University),
Gonul Sahin21
Estimated H-index: 21
(EMU: Eastern Mediterranean University),
Terken Baydar15
Estimated H-index: 15
(Hacettepe University)
Sources
Abstract
Usage of inorganic ingredients like aluminium salts in cosmetics and personal care products has been a concern for producers and consumers. Although aluminium is used to treat hyperhidrosis, some worries have been raised about aluminium's role in breast cancer, breast cyst and Alzheimer's disease. The human population is exposed to aluminium from vaccines, diet, and drinking water, but the frequent use of aluminium-based cosmetics might add additional local exposure. This paper reviews literature to determine if aluminium-based products may pose potential harm to the body. The dermal absorption of aluminium is not widely understood. It is not yet known whether aluminium can travel from the skin to brain to cause Alzheimer's disease. Aluminium may cause gene instability, alter gene expression or enhance oxidative stress, but the carcinogenicity of aluminium has not been proved yet. Until now, epidemiological researches were based on oral information, which lacks consistency, and the results are conflicting. Future studies should target real-life-based long-time exposure to antiperspirants and other aluminium-containing cosmetics and personal care products.
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#1Xueqing Hu (BTBU: Beijing Technology and Business University)
#2Huaming He (BTBU: Beijing Technology and Business University)
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#1Matthew Mold (Keele University)H-Index: 12
#2Adam O'Farrell (Keele University)H-Index: 1
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#1Maximilian Letzel (FAU: University of Erlangen-Nuremberg)H-Index: 1
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A large number of possible risk factors have been associated with Alzheimer'sdisease (AD).This chapter discusses the validity of the major risk factors that have been identifiedincluding age, genetics, exposure to aluminum, head injury, malnutrition and diet,mitochondrial dysfunction, vascular disease, immune system dysfunction, and infectionand proposes a hypothesis to explain how these various risk factors may cause ADpathology.Rare forms of early-onset familial AD (FAD) are strongly linked to...
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A clinical pharmacokinetic study was performed in 12 healthy women to evaluate systemic exposure to aluminum following topical application of a representative antiperspirant formulation under real-life use conditions. A simple roll-on formulation containing an extremely rare isotope of aluminum (26 Al) chlorohydrate (ACH) was prepared to commercial specifications. A 26 Al radio-microtracer was used to distinguish dosed aluminum from natural background, using accelerated mass spectroscopy. The 26...
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The SCCS adopted this guidance document at its plenary meeting on 24 – 25 October 2018 (152 pages) https://ec.europa.eu/health/sites/health/files/scientific_committees/consumer_safety/docs/sccs_o_224.pdf
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