A three-step enantioselective synthesis of (+)- and (−)-α-thujone
Abstract
The stereocontrolled three-step synthesis of either enantiomer of α-thujone from commercially available 3-methyl-1-butyne is described. The enantioselectivity originates from a Brown crotylation which is then conferred to the all-carbon quaternary center via chirality transfer in a gold-catalyzed cycloisomerization. The route is highly atom economical and requires no protecting groups or redox...
Paper Details
Title
A three-step enantioselective synthesis of (+)- and (−)-α-thujone
Published Date
Jan 1, 2021
Volume
19
Issue
37
Pages
8018 - 8020
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