Is Fas‐mediated apoptosis of melanocytes indispensable in vitiligo?

With interest, we have read the article by Jimbo et al. in Experimental Dermatology.1 The authors reported that the Fas pathway is involved in CD8+ T-lymphocyte-dependent depigmentation in a vitiligo mouse model. Tumor necrosis factor (TNF)-α and interferon, (IFN)-γ whose expression is elevated in lesional skin of vitiligo patients, synergistically upregulated Fas expression but suppressed Fas-mediated apoptosis of human melanocytes in vitro....