Aryl Hydrocarbon Receptor Controls Skin Homeostasis, Regeneration, and Hair Follicle Cycling by Adjusting Epidermal Stem Cell Function

Skin integrity requires constant maintenance of a quiescent, yet responsive, population of stem cells. While interfollicular epidermal progenitors control normal homeostasis, hair follicle stem cells residing within the bulge provide regenerative potential during hair cycle and in response to wounding. The aryl hydrocarbon receptor (AhR) modulates cell plasticity and differentiation and its overactivation results in severe skin lesions in...