Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure
Abstract
•Metabolic and transcriptional phenotypes of leukocytes from patients with ACLF were assessed.•Two break-points were discovered in the tricarboxylic cycle of leukocytes in ACLF.•Biomarkers of mitochondrial dysfunction correlated with inflammation and gene sets related to leukocyte activation.•Leukocyte mitochondrial dysfunction is a hallmark of ACLF. Background & AimsPatients with acute-on-chronic liver failure (ACLF) present a systemic...
Paper Details
Title
Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure
Published Date
Jan 1, 2022
Journal
Volume
76
Issue
1
Pages
93 - 106
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