Skin Autofluorescence, a Noninvasive Biomarker for Advanced Glycation End-products, Is Associated With Sarcopenia

Accumulation of advanced glycation end-products (AGEs) in skeletal muscle has been implicated in development of sarcopenia.To obtain further insight in the pathophysiology of sarcopenia, we studied its relationship with skin AGEs in the general population.In a cross-sectional analysis, 2744 participants of northern European background, mean age 74.1 years, were included from the Rotterdam Study. Skin AGEs were measured as skin autofluorescence...