Mechanism‐based therapeutic targets of pemphigus vulgaris: A scoping review of pathogenic molecular pathways

Volume: 31, Issue: 2, Pages: 154 - 171
Published: Sep 2, 2021
Abstract
Pemphigus vulgaris (PV) is a potentially fatal autoimmune blistering disease characterised by cell-cell detachment or acantholysis. The mechanisms which follow antibody (Ab) binding and culminate in acantholytic changes and skin/mucosal blistering have not been fully clarified. Current treatment strategies are not specific to PV pathophysiology and although life-saving, harbour considerable side effects. We aimed to systematically assess the...
Paper Details
Title
Mechanism‐based therapeutic targets of pemphigus vulgaris: A scoping review of pathogenic molecular pathways
Published Date
Sep 2, 2021
Volume
31
Issue
2
Pages
154 - 171
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