SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis

Volume: 13, Issue: 1, Pages: 173 - 191
Published: Jan 1, 2022
Abstract
Spleen tyrosine kinase (SYK) signaling pathway regulates critical processes in innate immunity, but its role in parenchymal cells remains elusive in chronic liver diseases. We investigate the relative contribution of SYK and its substrate c-Abl Src homology 3 domain-binding protein-2 (3BP2) in both myeloid cells and hepatocytes in the onset of metabolic steatohepatitis.Hepatic SYK-3BP2 pathway was evaluated in mouse models of...
Paper Details
Title
SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis
Published Date
Jan 1, 2022
Journal
Volume
13
Issue
1
Pages
173 - 191
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