Synergistic Copper and Chiral Lewis Base Catalysis for the Asymmetric Synthesis of Pyrrolo[1,2‐a]indoles
Abstract
Main observation and conclusion The first asymmetric decarboxylative [3+2]‐cycloaddition of ethynyl indoloxazolidones with carboxylic acids has been developed under synergistic catalysis of copper and chiral Lewis base. This protocol provides a direct and modular approach to biologically important pyrrolo[1,2‐ a ]indoles bearing two vicinal stereogenic centers with excellent diastereo‐ and enantioselectivities (up to >20 : 1 dr and >99%...
Paper Details
Title
Synergistic Copper and Chiral Lewis Base Catalysis for the Asymmetric Synthesis of Pyrrolo[1,2‐a]indoles
Published Date
Oct 10, 2021
Journal
Volume
39
Issue
12
Pages
3292 - 3296
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