Regenerating dynamic organs using biomimetic patches.

Published on Aug 16, 2021in Trends in Biotechnology14.343
· DOI :10.1016/J.TIBTECH.2021.07.001
Parth Chansoria4
Estimated H-index: 4
(UNC: University of North Carolina at Chapel Hill),
Emma L. Etter (UNC: University of North Carolina at Chapel Hill), Juliane Nguyen17
Estimated H-index: 17
(UNC: University of North Carolina at Chapel Hill)
The regeneration of dynamic organs remains challenging because they are intrinsically anisotropic and undergo large volumetric deformation during normal or pathological function. This hampers the durability and applicability of regenerative medicine approaches. To address the challenges of organ dynamics, a new class of patches have emerged with anisotropic and auxetic properties that mimic native tissue biomechanics and accommodate volumetric deformation. Here, we outline the critical design, materials, and processing considerations for achieving optimal patch biomechanics according to target pathology and summarize recent advances in biomimetic patches for dynamic organ regeneration. Furthermore, we discuss the challenges and opportunities which, if overcome, would open up new applications in organ regeneration and expedite the clinical translation of patch-based therapeutics.
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