Synthetic modifications of abietane diterpene acids to potent antimicrobial agents
Abstract
Among abietane type semisynthetic diterpenoids, a series of quinopimaric and maleopimaric acid derivatives modified at the carboxyl and carbonyl groups, and in ring E were synthesised to obtain new compounds with antimicrobial potency against Mycobacterium tuberculosis H37Rv and key ESKAPE pathogens. It was found that compound 8 exhibited low toxicity to human embryonic kidney cell line HEK-293 (> 32 μg/mL) and showed significant bacteriostatic...
Paper Details
Title
Synthetic modifications of abietane diterpene acids to potent antimicrobial agents
Published Date
Aug 27, 2021
Journal
Volume
37
Issue
2
Pages
313 - 321
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