Traumatic Brain Injury Induces cGAS Activation and Type I Interferon Signaling in Aged Mice
Abstract
Aging adversely affects inflammatory processes in the brain, which has important implications in the progression of neurodegenerative disease. Following traumatic brain injury (TBI), aged animals exhibit worsened neurological function and exacerbated microglial-associated neuroinflammation. Type I Interferons (IFN-I) contribute to the development of TBI neuropathology. Further, the Cyclic GMP-AMP Synthase (cGAS) and Stimulator of Interferon...
Paper Details
Title
Traumatic Brain Injury Induces cGAS Activation and Type I Interferon Signaling in Aged Mice
Published Date
Aug 24, 2021
Journal
Volume
12
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