Chronic Inflammation in Ulcerative Colitis Causes Long-Term Changes in Goblet Cell Function

One of the features of ulcerative colitis (UC) is a defect in the protective mucus layer. This has been attributed to a reduced number of goblet cells (GCs). However, it is not known whether abnormal GC mucus secretion also contributes to the reduced mucus layer. Our aims were to investigate whether GC secretion was abnormal in UC and exists as a long-term effect of chronic inflammation.Colonoids were established from intestinal stem cells of...